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1

A multimodal nanoprobe for pancreatic beta-cell detection and amyloidosis mitigation

Xin, Fangyun, Li, Yuhuan, Fu, Changkui, Javed, Ibrahim, Huang, Xumin, Schaschkow, Anaïs, Garcia Ribeiro, Rita S., Gurzov, Esteban N., Davis, Thomas P., Zhang, Xiaoling, Ke, Pu Chun, Qiao, Ruirui

Journal:

Chemistry of Materials

Year:

2020

Language:

english

File:

PDF, 2.87 MB

english, 2020

2

Inhibition of hIAPP Amyloid Aggregation and Pancreatic β-Cell Toxicity by OH-Terminated PAMAM Dendrimer

Gurzov, Esteban N., Wang, Bo, Pilkington, Emily H., Chen, Pengyu, Kakinen, Aleksandr, Stanley, William J., Litwak, Sara A., Hanssen, Eric G., Davis, Thomas P., Ding, Feng, Ke, Pu Chun

Journal:

Year:

2016

Language:

english

File:

PDF, 2.96 MB

english, 2016

3

Protein tyrosine phosphatases: molecular switches in metabolism and diabetes

Gurzov, Esteban N., Stanley, William J., Brodnicki, Thomas C., Thomas, Helen E.

Journal:

Trends in Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

4

Paradoxical antiproliferative effect by a murine mammary tumor-derived epithelial cell line

Esteban N Gurzov, Sanaa M Nabha, Hamilto Yamamoto, Hong Meng, O Graciela Scharovsky, R Daniel Bonfil

Journal:

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

5

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

Gurzov, E N, Ortis, F, Cunha, D A, Gosset, G, Li, M, Cardozo, A K, Eizirik, D L

Journal:

Cell Death & Differentiation

Year:

2009

Language:

english

File:

PDF, 889 KB

english, 2009

6

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

Colli, Maikel L., Nogueira, Tatiane C., Allagnat, Florent, Cunha, Daniel A., Gurzov, Esteban N., Cardozo, Alessandra K., Roivainen, Merja, Beeck, Anne O., Eizirik, Decio L., Basler, Christopher F.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

7

Sweet Killing in Obesity and Diabetes: The Metabolic Role of the BH3-Only Protein BIM

Miani, Michela, Elvira, Bernat, Gurzov, Esteban N.

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 2.15 MB

english, 2018

8

Targeting c-Jun and JunB proteins as potential anticancer cell therapy

Gurzov, E N, Bakiri, L, Alfaro, J M, Wagner, E F, Izquierdo, M

Journal:

Year:

2007

Language:

english

File:

PDF, 630 KB

english, 2007

9

The Transcription Factor B-Cell Lymphoma (BCL)-6 Modulates Pancreatic β-Cell Inflammatory Responses

Igoillo-Esteve, Mariana, Gurzov, Esteban N., Eizirik, Décio L., Cnop, Miriam

Journal:

Year:

2011

File:

PDF, 1.46 MB

2011

10

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic -cell responses to the viral by-product double-stranded RNA

Colli, M. L., Moore, F., Gurzov, E. N., Ortis, F., Eizirik, D. L.

Journal:

Human Molecular Genetics

Year:

2010

Language:

english

File:

PDF, 499 KB

english, 2010

11

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Ge, Xinwei, Kakinen, Aleksandr, Gurzov, Esteban N., Yang, Wen, Pang, Lokman, Pilkington, Emily H., Govindan-Nedumpully, Praveen, Chen, Pengyu, Separovic, Frances, Davis, Thomas P., Ke, Pu Chun, Ding,

Journal:

Chemical Communications

Year:

2017

Language:

english

File:

PDF, 1.55 MB

english, 2017

12

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated -Cell Death

Arif, S., Moore, F., Marks, K., Bouckenooghe, T., Dayan, C. M., Planas, R., Vives-Pi, M., Powrie, J., Tree, T., Marchetti, P., Huang, G. C., Gurzov, E. N., Pujol-Borrell, R., Eizirik, D. L., Peakman,

Journal:

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

13

Cyclin E1 knockdown induces apoptosis in cancer cells

Gurzov, Esteban N., Izquierdo, Marta

Journal:

Neurological Research

Year:

2006

Language:

english

File:

PDF, 393 KB

english, 2006

14

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

Litwak, Sara A., Loh, Kim, Stanley, William J., Pappas, Evan G., Wali, Jibran A., Selck, Claudia, Strasser, Andreas, Thomas, Helen E., Gurzov, Esteban N.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

15

JunB protects β-cells from lipotoxicity via the XBP1–AKT pathway

Cunha, D A, Gurzov, E N, Naamane, N, Ortis, F, Cardozo, A K, Bugliani, M, Marchetti, P, Eizirik, D L, Cnop, M

Journal:

Cell Death & Differentiation

Year:

2014

Language:

english

File:

PDF, 2.25 MB

english, 2014

16

RNA interference against Hec1 inhibits tumor growth in vivo

Gurzov, E N, Izquierdo, M

Journal:

Year:

2005

Language:

english

File:

PDF, 271 KB

english, 2005

17

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species

Pilkington, Emily H., Gurzov, Esteban N., Kakinen, Aleksandr, Litwak, Sara A., Stanley, William J., Davis, Thomas P., Ke, Pu Chun

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.52 MB

english, 2016

18

Differential regulation of pro-inflammatory cytokine signalling by PTPs in pancreatic β-cells

Stanley, William J, Trivedi, Prerak M, Sutherland, Andrew P, Thomas, Helen, Gurzov, Esteban N

Journal:

Journal of Molecular Endocrinology

Year:

2017

Language:

english

File:

PDF, 5.90 MB

english, 2017

19

Bim deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells

Krishnamurthy, Balasubramanian, Chee, Jonathan, Jhala, Gaurang, Trivedi, Prerak, Catterall, Tara, Selck, Claudia, Gurzov, Esteban N., Brodnicki, Thomas C., Graham, Kate L., Wali, Jibran A., Zhan, Yifa

Journal:

Year:

2015

Language:

english

File:

PDF, 8.77 MB

english, 2015

20

Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells

F. Ortis, M. Miani, M.L. Colli, D.A. Cunha, E.N. Gurzov, F. Allagnat, A. Chariot, D.L. Eizirik

Journal:

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

21

Cytokines Tumor Necrosis Factor- and Interferon- Induce Pancreatic -Cell Apoptosis through STAT1-mediated Bim Protein Activation

Barthson, J., Germano, C. M., Moore, F., Maida, A., Drucker, D. J., Marchetti, P., Gysemans, C., Mathieu, C., Nunez, G., Jurisicova, A., Eizirik, D. L., Gurzov, E. N.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.65 MB

english, 2011

22

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Santin, I., Moore, F., Colli, M. L., Gurzov, E. N., Marselli, L., Marchetti, P., Eizirik, D. L.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

23

Multiscale Modeling of Dendrimers for Biological Applications

Wang, Bo, Gurzov, Esteban, Chun Ke, Pu, Ding, Feng

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 37 KB

english, 2016

24

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

Gurzov, Esteban N., Ortis, Fernanda, Bakiri, Latifa, Wagner, Erwin F., Eizirik, Decio L., Maedler, Kathrin

Journal:

Year:

2008

Language:

english

File:

PDF, 729 KB

english, 2008

25

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Gurzov, Esteban N., Tran, Melanie, Fernandez-Rojo, Manuel A., Merry, Troy L., Zhang, Xinmei, Xu, Yang, Fukushima, Atsushi, Waters, Michael J., Watt, Matthew J., Andrikopoulos, Sofianos, Neel, Benjamin

Journal:

Cell Metabolism

Year:

2014

Language:

english

File:

PDF, 5.67 MB

english, 2014

26

Novel Strategies to Protect and Visualize Pancreatic Î² Cells in Diabetes

Gurzov, Esteban N., Ke, Pu Chun, Ahlgren, Ulf, Garcia Ribeiro, Rita S., Gotthardt, Martin

Journal:

Trends in Endocrinology & Metabolism

Year:

2020

File:

PDF, 2.17 MB

2020

27

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

Esteban N. Gurzov, Decio L. Eizirik

Journal:

Trends in Cell Biology

Year:

2011

Language:

english

File:

PDF, 575 KB

english, 2011

28

Lipotoxic Stress Induces Pancreatic β -Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Litwak, Sara A., Wali, Jibran A., Pappas, Evan G., Saadi, Hamdi, Stanley, William J., Varanasi, L. Chitra, Kay, Thomas W. H., Thomas, Helen E., Gurzov, Esteban N.

Journal:

Journal of Diabetes Research

Year:

2015

Language:

english

File:

PDF, 6.27 MB

english, 2015

29

Can GABA turn pancreatic α-cells into β-cells?

Eizirik, Decio L., Gurzov, Esteban N.

Journal:

Nature Reviews Endocrinology (formerly Nature Clinical Practice Endocrinology & Metabolism)

Year:

2018

Language:

english

File:

PDF, 738 KB

english, 2018

30

The Transcription Factor B-Cell Lymphoma (BCL)-6 Modulates Pancreatic β-Cell Inflammatory Responses

Igoillo-Esteve, Mariana, Gurzov, Esteban N., Eizirik, Décio L., Cnop, Miriam

Journal:

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

31

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E

Journal:

Cell Death and Disease

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

32

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

Wali, Jibran A., Gurzov, Esteban N., Fynch, Stacey, Elkerbout, Lorraine, Kay, Thomas W., Masters, Seth L., Thomas, Helen E., Ojcius, David M.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.95 MB

english, 2014

33

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Grohmann, Marcus, Wiede, Florian, Dodd, Garron T., Gurzov, Esteban N., Ooi, Geraldine J., Butt, Tariq, Rasmiena, Aliki A., Kaur, Supreet, Gulati, Twishi, Goh, Pei K., Treloar, Aislinn E., Archer, Stua

Journal:

Year:

2018

Language:

english

File:

PDF, 13.01 MB

english, 2018

34

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

Shields, B. J., Wiede, F., Gurzov, E. N., Wee, K., Hauser, C., Zhu, H.-J., Molloy, T. J., O'Toole, S. A., Daly, R. J., Sutherland, R. L., Mitchell, C. A., McLean, C. A., Tiganis, T.

Journal:

Molecular and Cellular Biology

Year:

2013

Language:

english

File:

PDF, 3.42 MB

english, 2013

35

Star Polymers Reduce IAPP Toxicity via Accelerated Amyloid Aggregation

Pilkington, Emily H., Lai, May, Ge, Xinwei, Stanley, William J, Wang, Bo, Wang, Miaoyi, Kakinen, Aleksandr, Sani, Marc-Antoine, Whittaker, Michael R., Gurzov, Esteban N, Ding, Feng, Quinn, John F., Da

Journal:

Biomacromolecules

Year:

2017

Language:

english

File:

PDF, 1.93 MB

english, 2017

36

The JAK-STAT Pathway in Obesity And Diabetes

Gurzov, Esteban N., Stanley, William J., Pappas, Evan G., Thomas, Helen E., Gough, Daniel J.

Journal:

Year:

2016

Language:

english

File:

PDF, 665 KB

english, 2016

37

Inhibition of Y1 receptor signaling improves islet transplant outcome

Loh, Kim, Shi, Yan-Chuan, Walters, Stacey, Bensellam, Mohammed, Lee, Kailun, Dezaki, Katsuya, Nakata, Masanori, Ip, Chi Kin, Chan, Jeng Yie, Gurzov, Esteban N., Thomas, Helen E., Waibel, Michaela, Can

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

38

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells

Moore, Fabrice, Santin, Izortze, Nogueira, Tatiane C., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L., Rishi, Arun

Journal:

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

39

Glucagon-Like Peptide-1 Agonists Protect Pancreatic -Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Cunha, D. A., Ladriere, L., Ortis, F., Igoillo-Esteve, M., Gurzov, E. N., Lupi, R., Marchetti, P., Eizirik, D. L., Cnop, M.

Journal:

Year:

2009

Language:

english

File:

PDF, 419 KB

english, 2009

40

Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

Gurzov, E N, Barthson, J, Marhfour, I, Ortis, F, Naamane, N, Igoillo-Esteve, M, Gysemans, C, Mathieu, C, Kitajima, S, Marchetti, P, Ørntoft, T F, Bakiri, L, Wagner, E F, Eizirik, D L

Journal:

Year:

2012

Language:

english

File:

PDF, 715 KB

english, 2012

41

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic -Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

Gurzov, E. N., Germano, C. M., Cunha, D. A., Ortis, F., Vanderwinden, J.-M., Marchetti, P., Zhang, L., Eizirik, D. L.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.36 MB

english, 2010

42

STAT1 Is a Master Regulator of Pancreatic -Cell Apoptosis and Islet Inflammation

Moore, F., Naamane, N., Colli, M. L., Bouckenooghe, T., Ortis, F., Gurzov, E. N., Igoillo-Esteve, M., Mathieu, C., Bontempi, G., Thykjaer, T., Orntoft, T. F., Eizirik, D. L.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 5.56 MB

english, 2011

43

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

Stanley, William J., Litwak, Sara A., Quah, Hong Sheng, Tan, Sih Min, Kay, Thomas W.H., Tiganis, Tony, de Haan, Judy B., Thomas, Helen E., Gurzov, Esteban N.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.78 MB

english, 2015

44

Graphene oxide inhibits hIAPP amyloid fibrillation and toxicity in insulin-producing NIT-1 cells

Nedumpully-Govindan, Praveen, Gurzov, Esteban N., Chen, Pengyu, Pilkington, Emily H., Stanley, William J., Litwak, Sara A., Davis, Thomas P., Ke, Pu Chun, Ding, Feng

Journal:

Physical Chemistry Chemical Physics

Year:

2015

Language:

english

File:

PDF, 2.96 MB

english, 2015

45

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human -Cell Apoptosis

Cunha, D. A., Igoillo-Esteve, M., Gurzov, E. N., Germano, C. M., Naamane, N., Marhfour, I., Fukaya, M., Vanderwinden, J.-M., Gysemans, C., Mathieu, C., Marselli, L., Marchetti, P., Harding, H. P., Ron

Journal:

Year:

2012

Language:

english

File:

PDF, 1.91 MB

english, 2012

46

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

Wali, Jibran A, Galic, Sandra, Tan, Christina YR, Gurzov, Esteban N, Frazier, Ann E, Connor, Timothy, Ge, Jingjing, Pappas, Evan G, Stroud, David, Varanasi, L Chitra, Selck, Claudia, Ryan, Michael T,

Journal:

Cell Death & Differentiation

Year:

2017

Language:

english

File:

PDF, 486 KB

english, 2017

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